[Thesis]. Manchester, UK: The University of Manchester; 2018.
A unique characteristic of NMR is that, unlike other spectroscopic techniques, it
the excitation of signals from their detection. By manipulating the type of signal
used, the chemical information content of a spectrum can be controlled. This versatility
made NMR a powerful and flexible weapon in the analytical arsenal of chemists, not
for the determination of structural, chemical, dynamic, and physical properties of
molecules, but also for the analysis of mixtures, since NMR has the ability to study
intact without the need for physical separation.
Chapter 1 contains an introduction to the theoretical NMR background necessary for
Chapter 2, 3 and 6 detail the development of new methods that suppress 13C satellites
only in conventional 1D 1H and 19F spectra, but also in 1H DOSY spectra, and can facilitate
the analysis of minor components in high dynamic range mixtures (i.e. those with a
range of concentrations).
Chapter 4 introduces a new experiment which suppresses low-level artefacts in pure
NMR, and gives clean pure shift spectra that can be used for the detection of minor
components in the presence of strong signals.
Chapter 5 and 7 illustrate how 19F NMR can be exploited for the acquisition of simplified
proton spectra associated with a given 19F chemical shift, or for the virtual separation
mixture components using broadband 19F DOSY.
Chapter 8 summarises the conclusions extracted from the research introduced in the
body of this thesis, and gives suggestions for future developments.
Chapters 2, 3, 4, 5, and 7 contain published research articles and their Supporting
Information and are presented without modification. Chapter 6 is presented as a
manuscript intended for publication.