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Methods for Quantifying the Functional and Behavioural Effects of Psychotropic Agents
[Thesis]. Manchester, UK: The University of Manchester; 2016.
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Abstract
My research career started in 1971with a focus on the role of tryptophan in the control of brain serotonin metabolism. Since then I have worked in three academic laboratories and for four different pharmaceutical companies. I have published 169 peer reviewed articles in journals with high impact, including: Neuron; Journal of Neuroscience; Neuroimage, British Journal of Pharmacology; Psychopharmacology; Neuropsychopharmacology; Nature Reviews (Drug Discovery); Journal of Neurochemistry. According to Researchgate.net, my articles have been cited a total of 5,296 times (as of 16th November 2015). My Researchgate (RG score takes into account the impact factors of the citing journals and the frequency of citation and also the RG scores of those making the citation. As of 31st October 2015 my RG score was 42.01 and higher than 97.5% of all other Researchgate.net members. I have included the titles of 37 abstracts of papers presented at national and international meetings, but excluded copies of the abstracts for the DSc submission. I have worked pro bono for a number of scientific organisations including the Medical research Council, The British Pharmacological Society, The British Association for Psychopharmacology and the British Neuroscience Association. Using detailed behavioural analysis, my work has comprehensively examined serotonin from the perspective of its multiple receptor subtypes and their functional impact and has progressed to give a profile of what might be expected from highly novel compounds interacting with glutamate receptor subtypes. A key feature has been the evaluation of perturbations relevant to psychiatric disorders and ways in which the translational gap between preclinical and clinical research might be bridged. This led to the development of animal oxygen amperometry as a valid surrogate of human MRI BOLD imaging.