In April 2016 Manchester eScholar was replaced by the University of Manchester’s new Research Information Management System, Pure. In the autumn the University’s research outputs will be available to search and browse via a new Research Portal. Until then the University’s full publication record can be accessed via a temporary portal and the old eScholar content is available to search and browse via this archive.

Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis.

Bowes, John; Budu-Aggrey, Ashley; Huffmeier, Ulrike; Uebe, Steffen; Steel, Kathryn; Hebert, Harry L; Wallace, Chris; Massey, Jonathan; Bruce, Ian N; Bluett, James; Feletar, Marie; Morgan, Ann W; Marzo-Ortega, Helena; Donohoe, Gary; Morris, Derek W; Helliwell, Philip; Ryan, Anthony W; Kane, David; Warren, Richard B; Korendowych, Eleanor; Alenius, Gerd-Marie; Giardina, Emiliano; Packham, Jonathan; McManus, Ross; FitzGerald, Oliver; McHugh, Neil; Brown, Matthew A; Ho, Pauline; Behrens, Frank; Burkhardt, Harald; Reis, Andre; Barton, Anne

Nature communications. 2015;6:6046.

Access to files

Full-text and supplementary files are not available from Manchester eScholar. Full-text is available externally using the following links:

Full-text held externally


Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis and, despite the larger estimated heritability for PsA, the majority of genetic susceptibility loci identified to date are shared with psoriasis. Here, we present results from a case-control association study on 1,962 PsA patients and 8,923 controls using the Immunochip genotyping array. We identify eight loci passing genome-wide significance, secondary independent effects at three loci and a distinct PsA-specific variant at the IL23R locus. We report two novel loci and evidence of a novel PsA-specific association at chromosome 5q31. Imputation of classical HLA alleles, amino acids and SNPs across the MHC region highlights three independent associations to class I genes. Finally, we find an enrichment of associated variants to markers of open chromatin in CD8(+) memory primary T cells. This study identifies key insights into the genetics of PsA that could begin to explain fundamental differences between psoriasis and PsA.

Bibliographic metadata

Type of resource:
Content type:
Publication status:
Publication type:
Publication form:
Published date:
Journal title:
Abbreviated journal title:
Place of publication:
Digital Object Identifier:
Pubmed Identifier:
Pii Identifier:
Attached files embargo period:
Immediate release
Attached files release date:
6th February, 2015
Access state:

Record metadata

Manchester eScholar ID:
Created by:
Ingram, Mary
6th February, 2015, 10:20:11
Last modified by:
Ingram, Mary
Last modified:
10th February, 2016, 20:02:04

Can we help?

The library chat service will be available from 11am-3pm Monday to Friday (excluding Bank Holidays). You can also email your enquiry to us.