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- DOI: 10.1002/lary.24898
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No association between Apolipoprotein E or N-acetyltransferase 2 gene polymorphisms and age-related hearing loss
Dawes, P., Platt, H., Horan, M., Ollier, W., Munro, K., Pendleton, N., & Payton, A
The Laryngoscope. 2014;.
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Full-text held externally
- DOI: 10.1002/lary.24898
Abstract
Objective: Age-related hearing loss has a strong genetic component but there have been limited genetic studies in this field. Both N-acetyltransferase 2 and apolipoprotein E genes have previously been associated. However, these studies have either used small sample sizes, examined a limited number of polymorphisms or have produced conflicting results. Here we use a haplotype tagging approach to determine association with age-related hearing loss and investigate epistasis between these two genes. Study Design: Candidate gene association study of a continuous phenotype. Methods: We investigated haplotype tagging single nucleotide polymorphisms in the N-acetyltransferase 2 gene and the presence/absence of the apolipoprotein E ε4 allele for association with age-related hearing loss in a cohort of 265 Caucasian elderly volunteers from Greater Manchester, UK. Hearing phenotypes were generated using principal components analysis of the hearing threshold levels for the better ear (severity, slope and concavity). Genotype data for the N-acetyltransferase 2 gene was obtained from existing genome-wide association study data from the Illumina 610-Quadv1 chip. Apolipoprotein E genotyping was performed using Sequenom technology. Linear regression analysis was performed using Plink and Stata. Results: No significant associations (p-value, >0.05) were observed between the N-acetyltransferase 2 or apolipoprotein E gene polymorphisms and any hearing factor. No significant association was observed for epistasis analysis of apolipoprotein E ε4 and the N-acetyltransferase 2 single nucleotide polymorphism rs1799930 (NAT2*6A). Conclusion: We found no evidence that either N-acetyltransferase 2 or apolipoprotein E gene polymorphisms are associated with age-related hearing loss in a cohort of 265 elderly volunteers.
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