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Cross-Atlantic modification and validation of the - A Tool to Assess Quality of Life in Idiopathic Pulmonary Hypertension (ATAQ-cA)

Yorke, J., Spencer, L., Duck, A., Ratcliffe, S., Ng Man Kwong, G., Longshawe, M., Belkin, A., Swigris, J

B M J Open Respiratory Research. 2014;.

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Abstract

Rationale: The A Tool to Assess Quality of Life in Idiopathic Pulmonary Fibrosis (ATAQ-IPF) was developed in the USA to assess health-related quality of life in patients with IPF. It is likely that some of the original ATAQ-IPF items perform differently when applied in different countries. This paper reports results of a study conducted to identify the need to refine the content of the ATAQ-IPF to minimise crosscountry bias between the USA and the UK. Methods: The ATAQ-IPF and other study measures were completed by patients attending specialist IPF clinics in the USA and UK. Rasch analysis was used to determine which items performed differently across countries (USA vs UK) and refine the original ATAQ-IPF to an instrument without cross-country bias (ATAQ-IPF-cA). Preliminary validation of the modified instrument was examined by assessing correlations between ATAQ-IPF-cA scores and scores from dyspnoea-specific patient-reported outcome (PRO) measures. Results: 139 patients with IPF (USA=74; UK=65) participated in the study. A total of 41 items and 4 domains were removed from the original, 86-item instrument to yield the 43 items and 10 domains of the ATAQ-IPF-cA. Each domain had good fit to the Rasch model, internal consistency was comparable to the corresponding domains for the original ATAQ-IPF, and validity was supported by significant correlations between its scores and scores from dyspnoea-specific PROs. Conclusions: The reliability and validity of the substantially shortened ATAQ-IPF-cA are acceptable and comparable to the original instrument. We recommend use of the ATAQ-IPF-cA in IPF studies in which participants are enrolled from the USA and UK.

Bibliographic metadata

Type of resource:
Content type:
Publication status:
Published
Publication type:
Published date:
Language:
eng
Publisher:
Article number:
1:e000024.
Digital Object Identifier:
10.1136/bmjresp-2014-
Funding awarded externally:
Funder(s) acknowledged in this article?:
Yes
Is APC paid?:
Yes
Attached files embargo period:
Immediate release
Attached files release date:
19th May, 2014
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:225457
Created by:
Yorke, Janelle
Created:
19th May, 2014, 00:40:21
Last modified by:
Yorke, Janelle
Last modified:
24th May, 2014, 02:28:23

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