Related resources
Full-text held externally
- PMID: 20370364
- UKPMCID: 20370364
- DOI: 10.3109/13693780903225813
Search for item elsewhere
University researcher(s)
Academic department(s)
Exploring the concordance of Aspergillus fumigatus pathogenicity in mice and Toll-deficient flies.
Chamilos, Georgios; Bignell, Elaine M; Schrettl, Markus; Lewis, Russell E; Leventakos, Konstantinos; May, Gregory S; Haas, Hubertus; Kontoyiannis, Dimitrios P
Medical mycology : official publication of the International Society for Human and Animal Mycology. 2010;48(3):506-10.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Full-text is available externally using the following links:
Full-text held externally
- PMID: 20370364
- UKPMCID: 20370364
- DOI: 10.3109/13693780903225813
Abstract
The pathogenicity of six mutants of Aspergillus fumigatus that had been previously characterized in mice was assessed in Toll-deficient Drosophila melanogaster flies. Four out of six mutants of A. fumigatus, which displayed attenuated virulence in mice due to defects in siderophore biosynthesis (DeltasidA, DeltasidD), PABA metabolism (H515), and starvation stress response (DeltacpcA), also had attenuated virulence in the fly model. In addition, similarly to previous findings in the mouse model, DeltasidG mutant that is defective in extracellular siderophore biosynthesis retained full virulence in Toll-deficient flies. Overall, our studies reveal a high level of concordance between fly and murine models of invasive aspergillosis.