Arthritis Res. 2002;4, 5:302-306.
Studies have established the magnitude of the genetic basis of juvenile idiopathic
arthritis (JIA). JIA is a complex genetic condition and the genes that influence susceptibility
are actively being sought. A candidate gene approach is being used by several groups.
MHC-, cytokine- and T-cell-related genes have all been positively associated with
JIA. Here we review some of the latest genetic data, and discuss ways in which JIA
genetic research might proceed