Lack of association between intercellular adhesion molecule-1 gene polymorphisms and giant cell arteritis

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Abstract

OBJECTIVE: Studies have shown an association between HLA-DRB1*04 and giant cell arteritis (GCA). Intercellular adhesion molecule-1 (ICAM-1) gene polymorphisms were reported to contribute susceptibility to GCA in Italian patients where susceptibility to GCA is not associated with HLA-DRB1*04 alleles. ICAM-1 is also highly expressed within inflammatory infiltrates of the blood vessels of GCA patients. To investigate the clinical implications of ICAM-1 polymorphisms in GCA, we examined their potential association and influence in the development of visual ischemic complications in a series of patients with GCA from Northwest Spain where GCA susceptibility is associated with HLA-DRB1*04. METHODS: Fifty-eight biopsy proven GCA and 129 ethnically matched controls were studied. Patients and controls were genotyped for ICAM-1 polymorphism at codons 241 and 469 by PCR-RFLP. RESULTS: The distribution of the alleles and genotypes for each

Keyword(s)

Aged; Alleles; Anemia; Biopsy; Blood Vessels; Codon; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; HLA-DR Antigens; Human; Intercellular Adhesion Molecule-1; Ischemia; Male; Middle Age; Polymorphism (Genetics); Risk Factors; Spain; Temporal Arteritis; Vision Disorders; blood; complications; epidemiology; genetics; methods

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