HLA-B35 association with nephritis in Henoch-Schonlein purpura
Amoli MM, Thomson W, HajeerA.H, CalvinoM.C, Garcia-PorruaC, Ollier WER, Gonzalez-GayM.A
Journal of Rheumatology. 2002;29, 5:948-949.
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OBJECTIVE: To investigate the implications of the HLA-B locus in the susceptibility to Henoch-Schonlein purpura (HSP) and determine if there are associations with renal and gastrointestinal (GI) manifestations of the disease. METHODS: A retrospective study was performed on an unselected population of patients with HSP from Northwest Spain. Forty-eight Caucasian patients (24 women), 11 of them older than 20 years, were studied. Patients and ethnically matched controls were HLA-B genotyped from DNA using molecular based methods. RESULTS: When patients with HSP were compared with matched controls, no differences in HLA-B frequencies were observed. No HLA-B associations with GI manifestations were observed. In contrast, an increased frequency of HLA-B35 was observed in patients with renal manifestations (10 of 31) compared to those without (0 of 17). No significant distortions in frequency were seen for any other HLA-B alleles with HSP subgroups. CONCLUSION: Our results support a role of HLA-B35 in the susceptibility for nephritis in unselected patients with HSP
Adult; Alleles; Child; Disease; Dna; Female; Genotype; HLA-B35 Antigen; Human; Linkage Disequilibrium; Male; Nephritis; Phenotype; Purpura,Schoenlein-Henoch; Retrospective Studies; Role; Spain; epidemiology; genetics; immunology; methods