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HLA-B35 association with nephritis in Henoch-Schonlein purpura

Amoli MM, Thomson W, HajeerA.H, CalvinoM.C, Garcia-PorruaC, Ollier WER, Gonzalez-GayM.A

Journal of Rheumatology. 2002;29, 5:948-949.

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OBJECTIVE: To investigate the implications of the HLA-B locus in the susceptibility to Henoch-Schonlein purpura (HSP) and determine if there are associations with renal and gastrointestinal (GI) manifestations of the disease. METHODS: A retrospective study was performed on an unselected population of patients with HSP from Northwest Spain. Forty-eight Caucasian patients (24 women), 11 of them older than 20 years, were studied. Patients and ethnically matched controls were HLA-B genotyped from DNA using molecular based methods. RESULTS: When patients with HSP were compared with matched controls, no differences in HLA-B frequencies were observed. No HLA-B associations with GI manifestations were observed. In contrast, an increased frequency of HLA-B35 was observed in patients with renal manifestations (10 of 31) compared to those without (0 of 17). No significant distortions in frequency were seen for any other HLA-B alleles with HSP subgroups. CONCLUSION: Our results support a role of HLA-B35 in the susceptibility for nephritis in unselected patients with HSP

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28th August, 2009, 23:17:47
Last modified:
19th January, 2015, 20:46:02