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- DOI: 10.1086/341947
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Association of symptomatic acute human parvovirus B19 infection with human leukocyte antigen class I and II alleles
KerrJ.R, MatteyD.L, Thomson W, Poulton K, Ollier WER
Journal of Infectious Diseases. 2002;186, 4:447-452.
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Full-text held externally
- DOI: 10.1086/341947
Abstract
To determine the effect of the major histocompatibility complex on the development of symptoms during acute human parvovirus B19 infection, we compared human leukocyte antigen (HLA) class I and II alleles in 36 patients with symptomatic acute B19 infection with those in >900 control subjects from northwestern England. The frequency of each of HLA-DRB1*01 (P=.016), DRB1*04 (P=.007), and DRB1*07 (P<.0001) alleles was significantly higher in parvovirus B19 patients than in control subjects. In the parvovirus group, 63.9% carried the rheumatoid arthritis-associated shared epitope sequence, compared with 45% of control subjects (odds ratio [OR], 2.2; 95% confidence interval [CI], 0.97-4.8; P=.04), and carriage was associated with fatigue during the acute phase (OR, 4.2; 95% CI, 0.8-23.9; P=.047). All symptomatic parvovirus-associated HLA-DRB1 molecules carry a neutrally charged glutamine at position 10 and a positively charged lysine at position 12 of the first hypervariable region. HLA-B49 was associated with parvovirus infection independently of HLA-DRB1*01, DRB1*04, and DRB1*07
Keyword(s)
Acute Disease; Adolescent; Adult; Aged; Alleles; Amino Acid Sequence; Child; England; Female; Gene Frequency; Genes,MHC Class I; Genes,MHC Class II; HLA-B Antigens; HLA-DR Antigens; Human; Lung; Major Histocompatibility Complex; Male; Middle Age; Molecular Sequence Data; Odds Ratio; Parvoviridae Infections; Parvovirus B19,Human; Support,Non-U.S.Gov't; genetics; immunology; physiopathology
Bibliographic metadata
- UI - 22182925DA - 20020826IS - 0022-1899LA - engPT - Journal ArticleRN - 0 (HLA-B Antigens)RN - 0 (HLA-DR Antigens)RN - 128338-86-3 (HLA-DRB1)SB - AIMSB - IM