Association of symptomatic acute human parvovirus B19 infection with human leukocyte antigen class I and II alleles
KerrJ.R, MatteyD.L, Thomson W, Poulton K, Ollier WER
Journal of Infectious Diseases. 2002;186, 4:447-452.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Use our list of Related resources to find this item elsewhere.
To determine the effect of the major histocompatibility complex on the development of symptoms during acute human parvovirus B19 infection, we compared human leukocyte antigen (HLA) class I and II alleles in 36 patients with symptomatic acute B19 infection with those in >900 control subjects from northwestern England. The frequency of each of HLA-DRB1*01 (P=.016), DRB1*04 (P=.007), and DRB1*07 (P<.0001) alleles was significantly higher in parvovirus B19 patients than in control subjects. In the parvovirus group, 63.9% carried the rheumatoid arthritis-associated shared epitope sequence, compared with 45% of control subjects (odds ratio [OR], 2.2; 95% confidence interval [CI], 0.97-4.8; P=.04), and carriage was associated with fatigue during the acute phase (OR, 4.2; 95% CI, 0.8-23.9; P=.047). All symptomatic parvovirus-associated HLA-DRB1 molecules carry a neutrally charged glutamine at position 10 and a positively charged lysine at position 12 of the first hypervariable region. HLA-B49 was associated with parvovirus infection independently of HLA-DRB1*01, DRB1*04, and DRB1*07
Acute Disease; Adolescent; Adult; Aged; Alleles; Amino Acid Sequence; Child; England; Female; Gene Frequency; Genes,MHC Class I; Genes,MHC Class II; HLA-B Antigens; HLA-DR Antigens; Human; Lung; Major Histocompatibility Complex; Male; Middle Age; Molecular Sequence Data; Odds Ratio; Parvoviridae Infections; Parvovirus B19,Human; Support,Non-U.S.Gov't; genetics; immunology; physiopathology