Amoli MM, ShelleyE, MatteyD.L, Garcia-PorruaC, Thomson W, HajeerA.H, Ollier WER, Gonzalez-GayM.A
Journal of Rheumatology. 2002;29, 3:502-504.
OBJECTIVE: In untreated polymyalgia rheumatica (PMR), high levels of circulating soluble
intercellular adhesion molecule-1 (ICAM-1) have been observed. To investigate the
clinical implication of ICAM-1 polymorphisms in isolated PMR, we examined their potential
influence in an unselected series of patients. METHODS: We studied 72 patients with
isolated PMR and 129 ethnically matched controls from Lugo, Spain. Patients and controls
were genotyped for HLA-DRB1 and ICAM-1 polymorphism at codons 241 and 469 by molecular
methods. RESULTS: The distribution of alleles and genotypes for each ICAM-1 polymorphism
did not show significant differences between patients with isolated PMR and controls.
There were also no associations between ICAM-1 polymorphisms and relapses of the disease.
The latter was primarily associated with carriage of an HLA-DRB1*0401 allele (OR 7.2,
p = 0.01), although all relapsed patients with HLA-DRB1*0401 also carried the GG genotype
of the ICAM-1 polymorphism at codon 241. The presence of both HLA-DRB1*0401 and the
GG241 ICAM-1 genotype gave an OR of 15.2 (p = 0.005) after correction for age and
sex. CONCLUSION: Although ICAM-1 polymorphisms alone do not appear to be associated
with disease severity in isolated PMR, the presence of both HLA-DRB1*0401 and the
ICAM-1 codon 241 GG homozygosity was significantly associated with increased risk
of relapses in these patients