Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis.
Donn RP, FarhanA, StevansA, RamananA, Ollier WER, Thomson W
Rheumatology (Oxford). 2002;41, 8:930-936.
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OBJECTIVE:To investigate the involvement of neuroendocrine candidate genes in the aetiopathogenesis of juvenile idiopathic arthritis (JIA). METHODS:Single-nucleotide polymorphisms and intragenic microsatellite markers within five neuroendocrine candidate genes (CRH, CBG, CYP19, ESR1, PRL) were investigated in 463 clinically characterized UK Caucasian JIA patients and a panel of 276 unrelated, healthy UK Caucasian controls. RESULTS:None of the polymorphisms investigated showed any statistically significant associations with JIA. CONCLUSIONS:The lack of association with polymorphisms of these neuroendocrine genes suggests that they are not involved in susceptibility to JIA