Rheumatology (Oxford). 2002;41, 8:930-936.
OBJECTIVE:To investigate the involvement of neuroendocrine candidate genes in the
aetiopathogenesis of juvenile idiopathic arthritis (JIA). METHODS:Single-nucleotide
polymorphisms and intragenic microsatellite markers within five neuroendocrine candidate
genes (CRH, CBG, CYP19, ESR1, PRL) were investigated in 463 clinically characterized
UK Caucasian JIA patients and a panel of 276 unrelated, healthy UK Caucasian controls.
RESULTS:None of the polymorphisms investigated showed any statistically significant
associations with JIA. CONCLUSIONS:The lack of association with polymorphisms of these
neuroendocrine genes suggests that they are not involved in susceptibility to JIA