[University home]

The University of Manchester Library

Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis

Zeggini E, Thomson W, AlansariA, Ollier WER, Donn RP, British Paediatric Rheumatology Study Group

Rheumatology (Oxford). 2002;41, 4:462-465.

Access to files

Full-text and supplementary files are not available from Manchester eScholar. Use our list of Related resources to find this item elsewhere.

Abstract

OBJECTIVES: Juvenile idiopathic arthritis (JIA) is a complex polygenic disorder. The encouraging outcome of anti-tumour necrosis factor (TNF) treatment, as well as serological studies, has implicated TNF and its receptors (TNFRI and TNFRII, or TNFRSF1B) in the pathogenesis of JIA. The purpose of this study was to investigate the exon 6 TNFRII single nucleotide polymorphism (SNP) in a well-defined UK cohort of JIA patients, using case-control association analysis. METHODS: A total of 435 patients, spanning seven JIA subgroups, and 261 healthy individuals were screened for the polymorphism using the polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) method. RESULTS: No significant differences were observed between the SNP allelic or genotypic frequencies of patients and controls, or between JIA subgroups. CONCLUSIONS: This TNFRII exon 6 SNP does not seem to be associated with susceptibility to JIA

Bibliographic metadata

Type of resource:
Content type:
Publication type:
Publication form:
Published date:
Journal title:
Volume:
41, 4
Start page:
462
End page:
465
Pagination:
462 - 465
Access state:
Active

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:1d3698
Created:
28th August, 2009, 22:36:31
Last modified:
21st September, 2012, 18:24:45