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A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis

Donn RP, ShelleyE, Ollier WER, Thomson W, British Paediatric Rheumatology Study Group

Arthritis and Rheumatism. 2001;44, 8:1782-1785.

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Abstract

OBJECTIVE: To determine if polymorphisms of the macrophage migration inhibitory factor (MIF) gene are associated with systemic-onset juvenile idiopathic arthritis (JIA). METHODS: Denaturing high-performance liquid chromatography was used to screen for the MIF gene in 32 healthy Caucasian subjects. One hundred seventeen UK Caucasian patients with systemic-onset JIA and 172 unrelated healthy UK Caucasian controls were genotyped for a single-nucleotide polymorphism (SNP) identified in the 5'-flanking region of the gene, using polymerase chain reaction-restriction fragment length analysis. RESULTS: A G-to-C transition was identified at position -173 of the MIF gene. The presence of a C at -173 creates an activator protein 4 transcription factor binding site. Allele and genotype frequencies differed significantly between the patients and controls for the MIF-173 polymorphism. Individuals possessing a MIF-173*C allele have an increased risk of systemic-onset JIA (36.8% versus 20.3%) (odds ratio 2.3, 95% confidence interval 1.34-3.86; P = 0.0005). CONCLUSION: This is the first report of a SNP in the MIF gene. This polymorphism is associated with systemic-onset JIA

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Volume:
44, 8
Start page:
1782
End page:
1785
Pagination:
1782 - 1785
Digital Object Identifier:
10.1002/1529-0131(200108)44:8<1782::AID-ART314>3.0.CO;2-#
Access state:
Active

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:1d3651
Created:
28th August, 2009, 22:35:32
Last modified:
20th September, 2015, 12:15:32

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