Experimental Clinical Endocrinology and Diabetes. 2005;113:522-528.
Department of Endocrinology, University of Manchester, Salford NHS Trust, Salford,
UK. email@example.comHepatic sex-hormone binding globulin (SHBG) production
is down-regulated by insulin and low levels reflect insulin resistance. Because insulin
resistance is closely related to the development of cardiovascular disease in different
ethnic groups we examined ethnic variation in SHBG across populations with different
baseline cardiovascular risk and metabolic syndrome prevalence. Participants were
population-based, of European (n = 142), Pakistani (n = 130), and African-Caribbean
(AfC) origin (n = 193). SHBG, fasting lipids, and glucose concentrations plus insulin
sensitivity (HOMA-S) were determined. Age adjusted SHBG was significantly lower in
both Pakistani men and women. Circulating SHBG levels were lower in those with impaired
vs. normal glucose homeostasis. SHBG correlated positively with HOMA-S (rho = 0.28,
p < 0.001), and negatively with WHR (rho = - 0.38, p < 0.001), BMI (r = - 0.30, p
< 0.001), and diastolic blood pressure (rho = - 0.14, p < 0.01) across all ethnic
groups. In multivariate logistic regression analysis a low SHBG increased the likelihood
of the metabolic syndrome (odds ratio [OR] = 0.42 [0.21 - 0.82], p = 0.01) as did
higher fasting NEFA (OR 1.47 [1.04 - 2.08], p = 0.03), low IGFBP-1 concentrations
(OR 0.6 [0.44 - 0.81], p = 0.001), age (OR 1.05 [1.02 - 1.09], p = 0.003), and Pakistani
ethnicity (p = 0.001) in a model which also contained gender, lnCRP, IGF-I, and IGF-II.
As ethnic differences in SHBG level closely parallel differences in insulin resistance.
Its measurement may be useful in identifying individuals at particular risk of the
metabolic syndrome, for early intervention.PMID: 16235154 [PubMed - indexed for MEDLINE]