LĂĽbeck, R, Berneburg, M, Trelles, M, Friguet, B, Ogden, S, Esrefoglu, M, Kaya, G,
Goldberg, D, Mordon, S, Calderhead, R, Griffiths, CEM, Saurat, J, Thappa, D
Exp Dermatol. 2008;17( 3):228-40.
Once considered mainly a cosmetic issue, photoageing research has long moved to the
forefront of investigative dermatology. Besides obvious market pressures, increasing
insight into the mechanistic overlap between UV-induced skin cancer and UV-induced
skin ageing has contributed to this development. Also, as strategies that work to
antagonize intrinsic skin ageing/senescence may also be exploited against photoageing
(and vice versa!), it has become an important skin research challenge to dissect both
the differences and the overlap mechanisms between these interwined, yet distinct
phenomena. Finally, the current surge in putative 'antiageing' products, devices,
and strategies - too many of which boldly promise to fight and/or repair the perils
that come along with a lifetime spent in the sun in the absence of convincing evidence
of efficacy - makes it particularly pertinent to critically review the available evidence
to support often made antiageing claims. The current CONTROVERSIES feature, therefore,
aimed to provide both guidance through, and critical voices in, the antiageing circus.
Here, a panel of experts defines relevant key problems, points the uninaugurated to
intriguing aspects of photoageing that one may not have considered before, highlights
promising strategies for how best to halt and/or revert it, and spiritedly debates
some controversially discussed approaches.