Br J Psychiatry. 2008;192( 5):323-5.
We discuss the nature of intervention in developmental psychiatry and the implication
of this for clinical trials. New ideas in the design of randomised trials for complex
interventions, along with recent statistical advances in causal analysis, give such
trials additional potential as a means by which to study the basic science of complex
developmental disorders. The challenge for designers of trials is to model designs
effectively to make best use of these new opportunities. We give examples of how this
might be done and discuss implications for future trials designs in the area.