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- DOI: 10.1136/jmedgenet-2012-101156
- PMID: 23349225
- UKPMCID: 23349225
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Meta-analysis identifies a MECOM gene as a novel predisposing factor of osteoporotic fracture.
Hwang, Joo-Yeon; Lee, Seung Hun; Go, Min Jin; Kim, Beom-Jun; Kou, Ikuyo; Ikegawa, Shiro; Guo, Yan; Deng, Hong-Wen; Raychaudhuri, Soumya; Kim, Young Jin; Oh, Ji Hee; Kim, Youngdoe; Moon, Sanghoon; Kim, Dong-Joon; Koo, Heejo; Cha, My-Jung; Lee, Min Hye; Yun, Ji Young; Yoo, Hye-Sook; Kang, Young-Ah; Cho, Eun-Hee; Kim, Sang-Wook; Oh, Ki Won; Kang, Moo Il; Son, Ho Young; Kim, Shin-Yoon; Kim, Ghi Su; Han, Bok-Ghee; Cho, Yoon Shin; Cho, Myeong-Chan; Lee, Jong-Young; Koh, Jung-Min
Journal of medical genetics. 2013;187682.
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Full-text held externally
- DOI: 10.1136/jmedgenet-2012-101156
- PMID: 23349225
- UKPMCID: 23349225
Abstract
BACKGROUND: Osteoporotic fracture (OF) as a clinical endpoint is a major complication of osteoporosis. To screen for OF susceptibility genes, we performed a genome-wide association study and carried out de novo replication analysis of an East Asian population. METHODS: Association was tested using a logistic regression analysis. A meta-analysis was performed on the combined results using effect size and standard errors estimated for each study. RESULTS: In a combined meta-analysis of a discovery cohort (288 cases and 1139 controls), three hospital based sets in replication stage I (462 cases and 1745 controls), and an independent ethnic group in replication stage II (369 cases and 560 for controls), we identified a new locus associated with OF (rs784288 in the MECOM gene) that showed genome-wide significance (p=3.59Ă—10(-8); OR 1.39). RNA interference revealed that a MECOM knockdown suppresses osteoclastogenesis. CONCLUSIONS: Our findings provide new insights into the genetic architecture underlying OF in East Asians.
Bibliographic metadata
- Hwang, Joo-Yeon
- Lee, Seung Hun
- Go, Min Jin
- Kim, Beom-Jun
- Kou, Ikuyo
- Ikegawa, Shiro
- Guo, Yan
- Deng, Hong-Wen
- Raychaudhuri, Soumya
- Kim, Young Jin
- Oh, Ji Hee
- Kim, Youngdoe
- Moon, Sanghoon
- Kim, Dong-Joon
- Koo, Heejo
- Cha, My-Jung
- Lee, Min Hye
- Yun, Ji Young
- Yoo, Hye-Sook
- Kang, Young-Ah
- Cho, Eun-Hee
- Kim, Sang-Wook
- Oh, Ki Won
- Kang, Moo Il
- Son, Ho Young
- Kim, Shin-Yoon
- Kim, Ghi Su
- Han, Bok-Ghee
- Cho, Yoon Shin
- Cho, Myeong-Chan
- Lee, Jong-Young
- Koh, Jung-Min