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Modification of plasma insulin-like growth factors and binding proteins during oral contraceptive use and the normal menstrual cycle

Westwood, M; Gibson, J M; Pennells, L A; White, A

American Journal of Obstetrics and Gynecology. 1999;180(3):530-536.

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Abstract

OBJECTIVE: Sex steroid regulation of the insulin-like growth factor axis is a subject of contention. We examined the effect of combined oral contraceptives and investigated the cyclic variations in the insulin-like growth factor axis. STUDY DESIGN: Fasting blood samples were taken from 9 women receiving oral contraceptives, 10 women receiving no medication, and 10 male subjects. RESULTS: In women receiving oral contraceptives, insulin-like growth factor binding protein 1 remained highly phosphorylated and levels were acutely increased by sex steroid treatment (305 +/- 110 mu g/L on day 14 of the cycle [medication phase] vs 118 +/- 70 mu g/L during the medication-free period, P <.03). In women receiving no medication, insulin-like growth factor binding protein 1 levels were significantly lower (69 +/- 50 mu g/L. on day 14 of the menstrual cycle, P <.001) and varied cyclically with a rise in the late-secretory phase that coincided with the appearance of nonphosphorylated and less phosphorylated insulin-like growth factor binding protein 1 isoforms. Compared with those in untreated women and in men, insulin-like growth factor I levels were decreased in women receiving oral contraceptives (405 +/- 104 ng/mL in untreated women and 330 +/- 28 ng/mL in men vs 287 +/- 73 ng/mL in women receiving oral contraceptives, P<.004). Oral contraceptive use had no effect on insulin-like growth factor II levels, and neither insulin-like growth factor I nor insulin-like growth factor II showed cyclic variation. CONCLUSION: The bioavailability of insulin-like growth factor I is reduced in users of oral contraceptives. This may contribute to the metabolic changes observed in such subjects.

Bibliographic metadata

Type of resource:
Content type:
Published date:
Volume:
180
Issue:
3
Start page:
530
End page:
536
Total:
7
Pagination:
530-536
ISI Accession Number:
ISI:000079175300005
Related website(s):
  • Related website <Go to ISI>://000079175300005
General notes:
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:151218
Created by:
Gibson, Martin
Created:
15th January, 2012, 15:04:07
Last modified by:
Gibson, Martin
Last modified:
1st February, 2013, 19:46:21