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Epidemiology of the insulin-like growth factor system in three ethnic groups

Cruickshank, J K; Heald, A H; Anderson, S; Cade, J E; Sampayo, J; Riste, L K; Greenhalgh, A; Taylor, W; Fraser, W; White, A; Gibson, J M

American Journal of Epidemiology. 2001;154(6):504-513.

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Abstract

The insulin-like growth factor (IGF) system, comprising insulin-like growth factor I (IGF-I), insulin-like growth factor II (IGF-II), and their binding proteins (IGFBPs), is linked to cell growth, the development of cardiovascular disease, and several cancers. Little Is known about its epidemiology. The authors studied relations of the IGF system to anthropometric and metabolic variables in three population-based ethnic groups in Manchester; England, in 1994-1998 with differing disease risks: African Caribbean (n = 193), Pakistani (n = 130), and local Europeans(n = 142). Standardized anthropometry, glucose tolerance tests, and serum assays were performed. Body mass indices (BMIs) were high in all groups. IGF-I levels were highest in normoglycemic African Caribbeans and declined with age (r= -0.28). IGF-II levels were greatest in Europeans. IGFBP-1 concentrations increased with age in Pakistanis. (r = 0.20) and Europeans (r = 0.29), but not in African Caribbeans (r = 0.06), and were inversely related to BMI (r = -0.37). Age- and sex-adjusted IGFBP-1 was inversely related to fasting insulin and proinsulin in all groups; participants with newly detected diabetes were relatively insulinopenic but had higher IGFBP-1 concentrations. Nonesterified (free) fatty acid (NEFA) concentrations increased with declining glucose tolerance. In multiple regression analysis, IGFBP-1 was independently and negatively related to fasting insulin, BMI, and African-Carib bean compared with European ethnicity but positively related to age, fasting glucose, and NEFA. IGF-I was inversely related only to age, NEFA, and Pakistani ethnicity. IGF-II showed a strong ethnic difference but was unrelated to other variables. These data indicate considerable potential for exploring disease-IGF system relations in population samples.

Bibliographic metadata

Type of resource:
Content type:
Published date:
Volume:
154
Issue:
6
Start page:
504
End page:
513
Total:
10
Pagination:
504-513
Digital Object Identifier:
10.1093/aje/154.6.504
ISI Accession Number:
ISI:000171019800003
Related website(s):
  • Related website <Go to ISI>://000171019800003
Access state:
Active

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Record metadata

Manchester eScholar ID:
uk-ac-man-scw:151209
Created by:
Gibson, Martin
Created:
15th January, 2012, 15:04:02
Last modified by:
Gibson, Martin
Last modified:
1st February, 2013, 19:48:36