[University home]

The University of Manchester Library

Impaired glucose tolerance and insulin resistance in heart failure: underrecognized and undertreated?

Mamas, M A; Deaton, C; Rutter, M K; Yuille, M; Williams, S G; Ray, S G; New, J; Gibson, J M; Neyses, L

J Card Fail. 2010;16(9):761-8.

Access to files

Full-text and supplementary files are not available from Manchester eScholar. Use our list of Related resources to find this item elsewhere.

Abstract

BACKGROUND: A link between diabetes mellitus (DM) and heart failure (HF) has been well-recognized for more than a century. HF is also closely linked to abnormal glucose regulation (AGR) and insulin resistance (IR) in patients without DM and, similarly, these conditions commonly coexist. In epidemiological studies, each condition appears to predict the other. The prevalence of AGR/IR in HF patients without DM is significantly underrecognized and, as yet, the optimal method for screening for these abnormalities in the outpatient setting is unclear. METHODS AND RESULTS: The purpose of this review is to overview the prevalence and prognostic impact of AGR and IR in HF patients without DM and discuss potential pathophysiological pathways that link these conditions with HF. The severity of glucose intolerance in patients with HF correlates with functional and clinical severity of HF and is an independent predictor of an adverse outcome. It is thought that changes in cardiac metabolism, including a switch from glucose metabolism toward fatty acid metabolism, may in part contribute to the pathophysiological processes associated with HF patients with AGR/IR. CONCLUSIONS: We discuss how pharmacological targeting of metabolic pathways in the myocardium of these patients with HF may represent novel therapeutic strategies in these at-risk patients.

Bibliographic metadata

Type of resource:
Content type:
Published date:
Journal title:
Volume:
16
Issue:
9
Start page:
761
End page:
8
Total:
-752
Pagination:
761-8
Digital Object Identifier:
10.1016/j.cardfail.2010.05.027
ISI Accession Number:
20797600
Related website(s):
  • Related website http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20797600
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:151194
Created by:
Gibson, Martin
Created:
15th January, 2012, 14:48:48
Last modified by:
Gibson, Martin
Last modified:
1st February, 2013, 19:47:23