Related resources
Full-text held externally
- PMID: 21925771
- UKPMCID: 21925771
- DOI: 10.1016/j.neurobiolaging.2011.08.005
Search for item elsewhere
University researcher(s)
Academic department(s)
The chromosome 9 ALS and FTD locus is probably derived from a single founder.
Mok, Kin; Traynor, Bryan J; Schymick, Jennifer; Tienari, Pentti J; Laaksovirta, Hannu; Peuralinna, Terhi; Myllykangas, Liisa; Chiò, Adriano; Shatunov, Aleksey; Boeve, Bradley F; Boxer, Adam L; Dejesus-Hernandez, Mariely; Mackenzie, Ian R; Waite, Adrian; Williams, Nigel; Morris, Huw R; Simón-Sánchez, Javier; van Swieten, John C; Heutink, Peter; Restagno, Gabriella; Mora, Gabriele; Morrison, Karen E; Shaw, Pamela J; Rollinson, Pamela Sara; Al-Chalabi, Ammar; Rademakers, Rosa; Pickering-Brown, Stuart; Orrell, Richard W; Nalls, Michael A; Hardy, John
Neurobiology of aging. 2011;.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Full-text is available externally using the following links:
Full-text held externally
- PMID: 21925771
- UKPMCID: 21925771
- DOI: 10.1016/j.neurobiolaging.2011.08.005
Abstract
We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease.
Bibliographic metadata
- Mok, Kin
- Traynor, Bryan J
- Schymick, Jennifer
- Tienari, Pentti J
- Laaksovirta, Hannu
- Peuralinna, Terhi
- Myllykangas, Liisa
- Chiò, Adriano
- Shatunov, Aleksey
- Boeve, Bradley F
- Boxer, Adam L
- Dejesus-Hernandez, Mariely
- Mackenzie, Ian R
- Waite, Adrian
- Williams, Nigel
- Morris, Huw R
- Simón-Sánchez, Javier
- van Swieten, John C
- Heutink, Peter
- Restagno, Gabriella
- Mora, Gabriele
- Morrison, Karen E
- Shaw, Pamela J
- Rollinson, Pamela Sara
- Al-Chalabi, Ammar
- Rademakers, Rosa
- Pickering-Brown, Stuart
- Orrell, Richard W
- Nalls, Michael A
- Hardy, John