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Recent advances in the immunogenetics of idiopathic inflammatory myopathy.

Chinoy, Hector; Lamb, Janine A; Ollier, William ER; Cooper, Robert G

Arthritis research & therapy. 2011;13(3):216 (Epub ahead of print).

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Abstract

ABSTRACT: This review summarizes the previous and current literature on the immunogenetics of idiopathic inflammatory myopathy (IIM) and updates the research progress that has been made over the past decade. A substantial part of the genetic risk for developing adult- and juvenile-onset IIM lies within the major histocompatibility complex (MHC), and a tight relationship exists between individual human leukocyte antigen alleles and specific serological subtypes, which in turn dictate clinical disease phenotypes. Multiple genetic regions outside of the MHC are increasingly being identified in conferring IIM disease susceptibility. We are still challenged with the task of studying a serologically and clinically heterogeneous disorder that is rarer by orders of magnitude than the likes of rheumatoid arthritis. An ongoing and internationally coordinated IIM genome-wide association study may provide further insights into IIM immunogenetics.

Bibliographic metadata

Type of resource:
Content type:
Publication type:
Publication form:
Published date:
Abbreviated journal title:
ISSN:
Volume:
13
Issue:
3
Pagination:
216 (Epub ahead of print)
Digital Object Identifier:
10.1186/ar3327
Pubmed Identifier:
21658295
Pii Identifier:
ar3327
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:125810
Created by:
Hookway, Sue
Created:
1st July, 2011, 10:53:00
Last modified by:
Hookway, Sue
Last modified:
1st July, 2011, 10:55:38

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