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Exacerbation of atopic dermatitis after bacillus Calmette-Guérin vaccination.
Dalton, S J; Haeney, M R; Patel, L; David, T J
Journal of the Royal Society of Medicine. 1998;91(3):133-134.
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Abstract
In two children with atopic dermatitis, routine vaccination with bacillus Calmette-Guérin (BCG) was followed by severe exacerbation of skin disease. If the sequence is cause and effect, a possible mechanism is stimulation of a Th2 lymphocyte cytokine profile by the vaccine, with migration of activated lymphocytes to inflamed skin. In children with active atopic dermatitis, BCG vaccination is best deferred until remission.